Monoclonal Antibodies to the Rough Lipopolysaccharide of Neisseria meningitidis Protect Infant Rats From Meningococcal Infection

• Published in: The Journal of infectious diseases Vol. 158; no. 1; pp. 209 - 212
• Main Authors: Saukkonen, Kirsi, Leinonen, Maija, Käyhty, Helena, Abdillahi, Hussein, Poolman, Jan T.
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University Chicago Press 01.07.1988; University of Chicago Press
• Subjects: Animals; Antibodies; Antibodies, Bacterial - immunology; Antibodies, Bacterial - therapeutic use; Antibodies, Monoclonal - immunology; Antibodies, Monoclonal - therapeutic use; Ascitic Fluid; Bacteria; Bacteriology; Biological and medical sciences; Concise Clinical and Laboratory Communications; Fundamental and applied biological sciences. Psychology; Immunization, Passive; Isotypes; Lipopolysaccharides - immunology; Meningococcal infections; Meningococcal Infections - prevention & control; Microbiology; Monoclonal antibodies; Mortality; Neisseria meningitidis; Neisseria meningitidis - immunology; Polysaccharides; Rats; Vaccination; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies; Rough form; Rat; Neisseriaceae; Rodentia; Neisseria meningitidis; Monoclonal antibody; Infection; Vertebrata; Experimental disease; Mammalia; Newborn animal; Lipopolysaccharide; Bacteria; Micrococcales; Meningitis; Protection
• ISSN: 0022-1899; 1537-6613
• DOI: 10.1093/infdis/158.1.209

Neisseria meningitidis group B (MenB) causes most meningococcal disease occurring during nonepidemic periods. Investigators have been working on the development of MenB vaccines based on outer membrane proteins (OMP) or lipopolysaccharide (LPS). The authors developed an infant rat model for meningococcal infection in which the protective efficacy of different antibodies could be assayed. In this model they have shown that monoclonal antibodies to class 1 OMP (subtype-specific) were as protective against MenB infection as was antibody to the capsular polysaccharide. In the present study they investigated the role of antibodies to LPS in protection against meningococcal infection.