Chaperoning extended life

The capacity to moderate internal and external stress is arguably the central function regulating senescence in whole-animal ageing. During ageing, molecular chaperones such as heat-shock proteins are thought to combat stress-related senescent dysfunction. In transgenic Drosophila melanogaster, with...

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Bibliographic Details
Published inNature (London) Vol. 390; no. 6655; p. 30
Main Authors Tatar, Marc, Khazaeli, Aziz A, Curtsinger, James W
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 06.11.1997
Subjects
Aging
Aging - physiology
Animals
Animals, Genetically Modified
Drosophila melanogaster
Heat
Heat shock proteins
Hominids
HSP70 Heat-Shock Proteins - genetics
HSP70 Heat-Shock Proteins - physiology
Insects
Life expectancy
Longevity - physiology
Male
Senescence
Temperature
United States > US
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Summary:The capacity to moderate internal and external stress is arguably the central function regulating senescence in whole-animal ageing. During ageing, molecular chaperones such as heat-shock proteins are thought to combat stress-related senescent dysfunction. In transgenic Drosophila melanogaster, with varying copy numbers of the gene hsp70 encoding heat-shock protein hsp70, we found that heat-induced expression of hsp70 increased lifespan at normal temperatures. Only a brief, low level of expression was required to obtain a long-term improvement in survival.
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ISSN:0028-0836
1476-4687
DOI:10.1038/36237