Use of pentoxifylline and tocopherol in radiation-induced fibrosis and fibroatrophy

Abstract Radiation-induced fibrosis in the head and neck is a well-established pathophysiological process after radiotherapy. Recently pentoxifylline and tocopherol have been proposed as treatments to combat the late complications of radiation-induced fibrosis and a way of dealing with osteoradionec...

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Bibliographic Details
Published inBritish journal of oral & maxillofacial surgery Vol. 55; no. 3; pp. 235 - 241
Main Authors Patel, V, McGurk, M
Format Journal Article
LanguageEnglish
Published Scotland Elsevier Ltd 01.04.2017
Subjects
Antioxidants - therapeutic use
Atrophy - drug therapy
Atrophy - etiology
Dentistry
Fibrosis - drug therapy
Fibrosis - etiology
Humans
pentoxifylline
Pentoxifylline - therapeutic use
Radiation Injuries - drug therapy
Radiation Injuries - pathology
Radiation-induced fibrosis
Radiotherapy - adverse effects
Surgery
tocopherol
Tocopherols - therapeutic use
pentoxifylline
Radiation-induced fibrosis
tocopherol
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Summary:Abstract Radiation-induced fibrosis in the head and neck is a well-established pathophysiological process after radiotherapy. Recently pentoxifylline and tocopherol have been proposed as treatments to combat the late complications of radiation-induced fibrosis and a way of dealing with osteoradionecrosis. They both have a long history in the management of radiation-induced fibrosis at other anatomical sites. In this paper we review their use in sites other than the head and neck to illustrate the potential benefit that they offer to our patients.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0266-4356
1532-1940
DOI:10.1016/j.bjoms.2016.11.323