Distribution of High-risk Human Papillomavirus Genotypes in Cervical Secretions in Punjab
To determine the high risk-human papillomavirus (HR-HPV) prevalence, genotype distribution, and associated risk factors in women with general gynaecological problems. Descriptive, cross-sectional study. Lady Wallingdon Hospital, Lahore from August 2018 to May 2019. One hundred females with general g...
Saved in:
Published in | Journal of the College of Physicians and Surgeons--Pakistan Vol. 31; no. 7; pp. 786 - 791 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Pakistan
College of Physicians and Surgeons Pakistan
01.07.2021
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | To determine the high risk-human papillomavirus (HR-HPV) prevalence, genotype distribution, and associated risk factors in women with general gynaecological problems.
Descriptive, cross-sectional study.
Lady Wallingdon Hospital, Lahore from August 2018 to May 2019.
One hundred females with general gynaecological problems constituted the sample. Real-time polymerase chain reaction and liquid base cytology were performed for HR-HPV detection, genotyping, and cytological changes in cervical samples.
The overall prevalence of HR-HPV was found to be 57%, with the most frequent HR-HPV genotypes HPV 16 (18%), HPV 18 (6%), and HPV 45 (1%). The total prevalence of single HR-HPV infection was 25%; whereas, multiple co-infection of HR-HPV was seen in 32% of cases. In total, 81% of these women had normal cytology and 19% had cytologic abnormalities. A significant association was observed between HR-HPV infection and general gynaecological complaints and between HR-HPV infection and cytological abnormalities (p < 0.001).
The HR-HPV prevalence was 57% with the most prevalent genotypes were HPV 16 and HPV 18. The results will also aid the identification of HR-HPV 51 and 31 genotypes, which should be added in the multi-type HPV vaccines. Key Words: Cancer of cervix, Human papillomavirus, Papanicolaou test, Pakistan. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1022-386X 1681-7168 |
DOI: | 10.29271/jcpsp.2021.07.786 |