May Nesfatin-1 be a Biomarker in Acute Mesenteric Ischemia?

• Published in: Journal of the College of Physicians and Surgeons--Pakistan Vol. 29; no. 10; pp. 928 - 931
• Main Authors: Tatar, Cihad, Ahlatci, Fatih Alper, Idiz, Ufuk Oguz, Nayci, Ali Emre, Incir, Said, Agcaoglu, Orhan, Idiz, Cemile, Balik, Emre
• Format: Journal Article
• Language: English
• Published: Pakistan College of Physicians and Surgeons Pakistan 01.10.2019
• Subjects: Acute Disease; Animals; Biomarkers - blood; Disease Models, Animal; Ischemia; Male; Mesenteric Ischemia - blood; Nucleobindins - blood; Rats; Rats, Sprague-Dawley
• ISSN: 1022-386X; 1681-7168
• DOI: 10.29271/jcpsp.2019.10.928

To investigate the diagnostic value of nesfatin-1 in cases of intestinal ischemia and ischemia/reperfusion. An experimental study. The Experimental Animals Laboratory of Bezmialem University, in June 2018. Twenty-one healthy male Sprague Dawley rats were randomly divided into three groups of 7 rats each. In group 1: 1-hour intestinal ischemia followed by 5-hour reperfusion was performed. In group 2: rats were subjected to 6-hour intestinal ischemia. In group 3: rats underwent laparotomy and closure without performing any further procedure. Changes in leukocyte count, amylase, blood sugar, LDH, SGOT, CRP, and nesfatin-1 levels were determined. For histopathological examination, a small intestinal sample was taken and preserved in 10% formaldehyde. Nesfatin-1 value in group 2 was significantly higher than that in group 1 and group 3 (p=0.005, and p <0.001 respectively). Nesfatin-1 value in group 1 was significantly higher than that in group 3. A significant (r = 0.864/p <0.001) positive correlation was observed between nesfatin-1 value and pathology score. The pathology score of group 2 was significantly higher than that of group 1 and group 3 (p <0.001). Serum nesfatin-1 can be a biomarker in acute mesenteric ischemia.