Effects of acute ingestion of salbutamol during submaximal exercise

• Published in: International journal of sports medicine Vol. 21; no. 7; p. 480
• Main Authors: Collomp, K, Candau, R, Collomp, R, Carra, J, Lasne, F, Préfaut, C, De Ceaurriz, J
• Format: Journal Article
• Language: English
• Published: Germany 01.10.2000
• Subjects: Administration, Oral; Adrenergic beta-Agonists - administration & dosage; Adult; Albuterol - administration & dosage; Bicycling; Blood Glucose - analysis; C-Peptide - blood; Double-Blind Method; Energy Metabolism - drug effects; Exercise Tolerance - drug effects; Fatty Acids, Nonesterified - blood; Humans; Lactates - blood; Male
• ISSN: 0172-4622; 1439-3964
• DOI: 10.1055/s-2000-7422

To assess the eventual effects of acute oral salbutamol intake on performance and metabolism during submaximal exercise, nine healthy volunteers completed two cycling trials at a power corresponding to 80-85% VO2max, after either placebo (Pla) or salbutamol (Sal, 6 mg) treatment, according to a double-blind randomized protocol. Blood samples were collected both at rest and during exercise (5 min-, 10 min-, 15 min-exhaustion) for C-peptide, FFA, lactate and blood glucose measurements. Cycling performance was significantly improved in the Sal vs. Pla trials (p < 0.05). After Sal intake, resting C-peptide, lactate, FFA and blood glucose values were higher whereas exercise lactate and free fatty acid concentrations were greater during and at the conclusion of the exercise period (p < 0.05). These results suggest that acute salbutamol ingestion improved performance during submaximal exercise probably through an enhancement of the overall contribution to energy production from both aerobic and anaerobic metabolisms.