Changes in antimicrobial resistance among Salmonella enterica subspecies enterica serovar Pullorum isolates in China from 1962 to 2007

• Published in: Veterinary microbiology Vol. 136; no. 3; pp. 387 - 392
• Main Authors: Pan, Zhiming, Wang, Xiaoquan, Zhang, Xiaoming, Geng, Shizhong, Chen, Xiang, Pan, Weijuan, Cong, Qiuxia, Liu, Xuexian, Jiao, Xinan, Liu, Xiufan
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 12.05.2009; Amsterdam; New York: Elsevier; Elsevier
• Subjects: Animals; Anti-Bacterial Agents - pharmacology; antibiotic resistance; antibiotics; Antimicrobial resistance; Bacteriology; Biological and medical sciences; Chickens; China; China - epidemiology; disease detection; disease prevention; Drug Resistance, Multiple, Bacterial; drug therapy; epidemiological studies; food pathogens; Fundamental and applied biological sciences. Psychology; longitudinal studies; Microbial Sensitivity Tests - veterinary; Microbiology; Miscellaneous; multiple drug resistance; pathotypes; poultry diseases; Poultry Diseases - drug therapy; Poultry Diseases - epidemiology; Poultry Diseases - microbiology; pullorum disease; Retrospective Studies; risk assessment; Salmonella enterica - drug effects; Salmonella enterica - growth & development; Salmonella enterica - isolation & purification; Salmonella enterica subsp. enterica serovar Pullorum; Salmonella enterica subspecies enterica serovar Pullorum; Salmonella Infections, Animal - drug therapy; Salmonella Infections, Animal - epidemiology; Salmonella Infections, Animal - microbiology; serotypes; temporal variation; China; Asia; Salmonella enterica subspecies enterica serovar Pullorum; China; Antimicrobial resistance; Resistance; Salmonella; Microbiology; Bacteria; Isolate; Veterinary; Antimicrobial agent; Enterobacteriaceae
• ISSN: 0378-1135; 1873-2542
• DOI: 10.1016/j.vetmic.2008.11.015

There are few data available for the trends of antimicrobial resistance of Salmonella enterica subspecies enterica serovar Pullorum ( S. Pullorum) in China and other parts of the world. Thus, the objective of this study was to evaluate the changes in antimicrobial resistance of S. Pullorum isolated from diseased chickens in China from 1962 to 2007. A total of 450 S. Pullorum isolates were tested for their susceptibility to 17 antimicrobials in a disk diffusion method. 39–95% of the isolates displayed a high level of resistance, particularly against ampicillin, carbenicillin, streptomycin, tetracycline, trimethoprim and sulfafurazole. Isolates exhibited increased resistance to carbenicillin, spectinomycin, trimethoprim, trimethoprim/sulfamethoxazole and nalidixic acid during the study period. Moreover, 56.2% of the isolates exhibited multiple drug resistance (MDR; resistance ≥ 4 antimicrobials) and showed an increasing trend between 1970–1979 and 2000–2007. Therefore, the results suggest that certain measures, including continued surveillance of antimicrobial resistance and the rational use of antimicrobials, are necessary and important in order to control the rapid increase in antimicrobial resistance in S. Pullorum.