CT perfusion in hepatocellular carcinoma: Is it reliable?

Ninety percent of hepatic cancers are hepatocellular carcinomas (HCC) which have an unfavorable prognosis. HCC is a hypervascular tumor supplied mainly by the hepatic artery. It has a higher blood supply than the surrounding hepatic tissue due to neovascularization. Computed tomography with perfusio...

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Published inEgyptian journal of radiology and nuclear medicine Vol. 48; no. 4; pp. 791 - 798
Main Authors Hatem Shalaby, Mennatallah, Ali Shehata, Khaled A.
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.12.2017
SpringerOpen
Subjects
HCC
perfusion CT
Perfusion parameters
RFA
TACE
TACE
HCC
RFA
perfusion CT
Perfusion parameters
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Summary:Ninety percent of hepatic cancers are hepatocellular carcinomas (HCC) which have an unfavorable prognosis. HCC is a hypervascular tumor supplied mainly by the hepatic artery. It has a higher blood supply than the surrounding hepatic tissue due to neovascularization. Computed tomography with perfusion imaging (CTP) is a non invasive tool which quantifies the blood flow parameters of HCC and compares it to the surrounding tissue. To prove that CTP is a valuable diagnostic tool in diagnosis of HCC and posttherapeutic assessment. One hundred and twenty-six HCC patients with 150 focal lesions are enrolled this study. Perfusion parameters are quantified and results are compared to those of triphasic CT. CTP detected 141 lesions with 94% sensitivity and 40% specificity with elevated arterial perfusion (AP) and perfusion index (PI) with low portal flow (PF). It missed 5 lesions because of their hypovascularity and 4 lesions following radiofrequency ablation (RFA) and trans arterial chemo embolization (TACE). CTP is a safe and specific imaging tool for diagnosis and assessment of therapeutic interventional procedures in HCC.
ISSN:0378-603X
DOI:10.1016/j.ejrnm.2017.07.013