Excessive Apoptosis in Ulcerative Colitis: Crosstalk Between Apoptosis, ROS, ER Stress, and Intestinal Homeostasis

• Published in: Inflammatory bowel diseases Vol. 28; no. 4; pp. 639 - 648
• Main Authors: Wan, Yue, Yang, Lei, Jiang, Shu, Qian, Dawei, Duan, Jinao
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 30.03.2022
• Subjects: Apoptosis; Colitis, Ulcerative - drug therapy; Endoplasmic Reticulum Stress; Homeostasis; Humans; Inflammatory bowel disease; Intestinal Mucosa - pathology; Pathogenesis; Reactive Oxygen Species - metabolism; apoptosis; ulcerative colitis; intestinal homeostasis; endoplasmic reticulum stress; reactive oxygen species
• ISSN: 1078-0998; 1536-4844; 1536-4844
• DOI: 10.1093/ibd/izab277

Abstract Ulcerative colitis (UC), an etiologically complicated and relapsing gastrointestinal disease, is characterized by the damage of mucosal epithelium and destruction of the intestinal homeostasis, which has caused a huge social and economic burden on the health system all over the world. Its pathogenesis is multifactorial, including environmental factors, genetic susceptibility, epithelial barrier defect, symbiotic flora imbalance, and dysregulated immune response. Thus far, although immune cells have become the focus of most research, it is increasingly clear that intestinal epithelial cells play an important role in the pathogenesis and progression of UC. Notably, apoptosis is a vital catabolic process in cells, which is crucial to maintain the stability of intestinal environment and regulate intestinal ecology. In this review, the mechanism of apoptosis induced by reactive oxygen species and endoplasmic reticulum stress, as well as excessive apoptosis in intestinal epithelial dysfunction and gut microbiology imbalance are systematically and comprehensively summarized. Further understanding the role of apoptosis in the pathogenesis of UC may provide a novel strategy for its therapy in clinical practices and the development of new drugs. Lay Summary Recently, the prevalence of ulcerative colitis (UC) has increased, but the pathogenesis of UC remains poorly understood. A better understanding of the role of apoptosis in the pathogenesis of UC may provide a promising prospect for UC treatment.