Genetic mapping of mouse centromere protein (Incenp and Cenpe) genes

Inner centromere protein (INCENP) and centromere protein E (CENPE) are two functionally important proteins of the higher eukaryotic centromere. Using a mouse Incenp genomic DNA and a mouse Cenpe cDNA to analyze recombinant inbred mouse sets, as well as interspecific backcross panels, we have mapped...

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Published inCytogenetic and genome research Vol. 82; no. 1-2; pp. 67 - 70
Main Authors FOWLER, K. J, SAFFERY, R, KILE, B. T, IRVINE, D. V, HUDSON, D. F, TROWELL, H. E, CHOO, K. H. A
Format Conference Proceeding Journal Article
LanguageEnglish
Published Freiburg Karger 01.01.1998
Basel S. Karger AG
Paris
Subjects
Animals
Biological and medical sciences
Centromere - genetics
Chromosomal Proteins, Non-Histone - genetics
Chromosome Mapping
Classical genetics, quantitative genetics, hybrids
DNA, Complementary
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
Haplotypes
Mice
Vertebrata
Genetic mapping
Chromosome 19
Vertebrata
Mammalia
Centromere
Gene
Mouse
Rodentia
Chromosome 6
Nuclear protein
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Summary:Inner centromere protein (INCENP) and centromere protein E (CENPE) are two functionally important proteins of the higher eukaryotic centromere. Using a mouse Incenp genomic DNA and a mouse Cenpe cDNA to analyze recombinant inbred mouse sets, as well as interspecific backcross panels, we have mapped these genes to the proximal regions of mouse Chromosomes 19 and 6, respectively. Comparison of Cenpe and human CENPE, which maps to chromosome region 4q24-->q25, has further identified a new region of homology between the two species.
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ISSN:0301-0171
1424-8581
1424-859X
DOI:10.1159/000015066