The role of complement in the acute phase response after burns

Highlights • There is a prolonged acute phase response (for months up to a year) after-burn. • Persistently elevated complement in blood can cause adverse effects in patients. • Prolonged complement activation causes local tissue damage, hampers wound healing. • Prolonged acute phase response induce...

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Bibliographic Details
Published inBurns Vol. 43; no. 7; pp. 1390 - 1399
Main Authors Korkmaz, H. Ibrahim, Krijnen, Paul A.J, Ulrich, Magda M.W, de Jong, E, van Zuijlen, Paul P.M, Niessen, Hans W.M
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.11.2017
Subjects
Acute phase response
Acute-Phase Proteins - immunology
Acute-Phase Reaction - immunology
Burn wound
Burns - immunology
C-Reactive Protein - immunology
Complement
Complement System Proteins - immunology
Critical Care
Humans
Inflammation
Time Factors
Wound Healing
Complement
Inflammation
Acute phase response
Burn wound
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Summary:Highlights • There is a prolonged acute phase response (for months up to a year) after-burn. • Persistently elevated complement in blood can cause adverse effects in patients. • Prolonged complement activation causes local tissue damage, hampers wound healing. • Prolonged acute phase response induces negative systemic effects in several organs.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0305-4179
1879-1409
DOI:10.1016/j.burns.2017.03.007