The use of fibrinogen uptake test in screening for deep vein thrombosis in patients with hip fracture

• Published in: Thrombosis research Vol. 60; no. 3; pp. 185 - 190
• Main Authors: Faunø, P., Suomalainen, O., Bergqvist, D., Fredin, H., Kettunen, K., Soimakallio, S., Cederholm, C., Karjalainen, P., Vissinger, H., Justesen, T.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Ltd 01.11.1990; Elsevier Science
• Subjects: 550601 - Medicine- Unsealed Radionuclides in Diagnostics; BETA DECAY RADIOISOTOPES; Biological and medical sciences; Blood coagulation; BLOOD COAGULATION FACTORS; BODY; BODY AREAS; BONE FRACTURES; CARDIOVASCULAR DISEASES; COAGULANTS; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; Deep vein thrombosis; DIAGNOSIS; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; FIBRINOGEN; Fibrinogen uptake test; GLOBULINS; HEMATOLOGIC AGENTS; HEMOSTATICS; Hip fracture; Hip Fractures - complications; Hip Fractures - diagnostic imaging; Hip Fractures - surgery; Humans; INJURIES; INTERMEDIATE MASS NUCLEI; Investigative techniques, diagnostic techniques (general aspects); IODINE 125; IODINE ISOTOPES; Iodine Radioisotopes; ISOTOPES; Mass Screening - methods; Medical sciences; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; PATIENTS; PELVIS; Phlebography; Postoperative Complications - diagnostic imaging; Predictive Value of Tests; PROTEINS; RADIOISOTOPE SCANNING; RADIOISOTOPES; RADIOLOGY AND NUCLEAR MEDICINE; Radionuclide Imaging; Thrombophlebitis - diagnostic imaging; Thrombophlebitis - etiology; THROMBOSIS; UPTAKE; VASCULAR DISEASES; Deep vein thrombosis; Hip fracture; Fibrinogen uptake test; Phlebography; Human; Radiolabelling; Efficiency; Test; Internalization; Clinical biology; Fibrinogen; Glycoproteins; Thrombosis
• ISSN: 0049-3848; 1879-2472
• DOI: 10.1016/0049-3848(90)90179-G

255 hip fracture patients were studied by 125I-fibrinogen uptake test and bilateral phlebography. We found the sensitivity of fibrinogen scanning to be 44% for the non-operated limb and 50% for the calves. The predictive value of a negative result was found to be 92% and 93% respectively. We conclude that the use of fibrinogen uptake test as single diagnosticum is not valid and can only be recommended in combination with phlebography when studying patient where the frequency of DVT is expected to be low.