3D Extracellular Matrix Mimics: Fundamental Concepts and Role of Materials Chemistry to Influence Stem Cell Fate

• Published in: Biomacromolecules Vol. 21; no. 6; pp. 1968 - 1994
• Main Authors: Nicolas, Julien, Magli, Sofia, Rabbachin, Linda, Sampaolesi, Susanna, Nicotra, Francesco, Russo, Laura
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 08.06.2020
• Subjects: biochemical compounds; chemistry; drugs; extracellular matrix; Life Sciences; medicine; stem cells

Synthetic 3D extracellular matrices (ECMs) find application in cell studies, regenerative medicine, and drug discovery. While cells cultured in a monolayer may exhibit unnatural behavior and develop very different phenotypes and genotypes than , great efforts in materials chemistry have been devoted...