3D Extracellular Matrix Mimics: Fundamental Concepts and Role of Materials Chemistry to Influence Stem Cell Fate

Synthetic 3D extracellular matrices (ECMs) find application in cell studies, regenerative medicine, and drug discovery. While cells cultured in a monolayer may exhibit unnatural behavior and develop very different phenotypes and genotypes than , great efforts in materials chemistry have been devoted...

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Published inBiomacromolecules Vol. 21; no. 6; pp. 1968 - 1994
Main Authors Nicolas, Julien, Magli, Sofia, Rabbachin, Linda, Sampaolesi, Susanna, Nicotra, Francesco, Russo, Laura
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 08.06.2020
Subjects
biochemical compounds
chemistry
drugs
extracellular matrix
Life Sciences
medicine
stem cells
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Summary:Synthetic 3D extracellular matrices (ECMs) find application in cell studies, regenerative medicine, and drug discovery. While cells cultured in a monolayer may exhibit unnatural behavior and develop very different phenotypes and genotypes than , great efforts in materials chemistry have been devoted to reproducing behavior in cell microenvironments. This requires fine-tuning the biochemical and structural actors in synthetic ECMs. This review will present the fundamentals of the ECM, cover the chemical and structural features of the scaffolds used to generate ECM mimics, discuss the nature of the signaling biomolecules required and exploited to generate bioresponsive cell microenvironments able to induce a specific cell fate, and highlight the synthetic strategies involved in creating functional 3D ECM mimics.
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ISSN:1525-7797
1526-4602
1526-4602
DOI:10.1021/acs.biomac.0c00045