Construction of sulfur-containing moieties in the total synthesis of natural products

• Published in: Natural product reports Vol. 37; no. 2; pp. 246 - 275
• Main Authors: Wang, Nengzhong, Saidhareddy, Puli, Jiang, Xuefeng
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 01.02.2020
• Subjects: Alkaloids - chemical synthesis; Alkaloids - chemistry; Biological Products - chemical synthesis; Biological Products - chemistry; Biological properties; Carbolines - chemical synthesis; Carbolines - chemistry; Chemists; Disaccharides - chemical synthesis; Disaccharides - chemistry; Disulfides - chemistry; drug development; Enediynes - chemical synthesis; Enediynes - chemistry; exhibitions; Ferrichrome - analogs & derivatives; Ferrichrome - chemical synthesis; Ferrichrome - chemistry; Indole Alkaloids - chemical synthesis; Indole Alkaloids - chemistry; Indoles - chemical synthesis; Indoles - chemistry; Isothiocyanates - chemical synthesis; Isothiocyanates - chemistry; medicinal properties; moieties; Molecular Structure; Natural products; objectives; Organic chemistry; Peptides, Cyclic - chemical synthesis; Peptides, Cyclic - chemistry; Piperazines - chemistry; Sulfates - chemistry; Sulfoxides - chemical synthesis; Sulfoxides - chemistry; Sulfur; Sulfur - chemistry; Sulfurization; surveys; Synthesis; Thiazoles - chemical synthesis; Thiazoles - chemistry
• ISSN: 0265-0568; 1460-4752; 1460-4752
• DOI: 10.1039/C8NP00093J

Covering: January 2013 to September 2018 Sulfur-containing natural products are a large class of significant functional molecules. Many of these compounds exhibit potent biological activities and pharmacological properties; in fact, some of them have been developed into important drugs. The total synthesis of sulfur-containing natural products is a subject that has long attracted significant attention from synthetic organic chemists; to achieve this goal, various methods have been developed over the past years. This review surveys total syntheses of sulfur-containing natural products that introduce sulfur atoms using different sulfurization agents to construct related sulfur-containing moieties.