Novel aza-BODIPY based small molecular NIR-II fluorophores for in vivo imaging

The development of new NIR-II fluorophores, particularly those with facile syntheses, high fluorescence quantum yields, and stable and tunable photophysical properties, is challenging. Herein, we report a new class of small molecular NIR-II fluorophores based on aza-dipyrromethene boron difluoride (...

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Published inChemical communications (Cambridge, England) Vol. 55; no. 73; pp. 10920 - 10923
Main Authors Bai, Lei, Sun, Pengfei, Liu, Yi, Zhang, Hang, Hu, Wenbo, Zhang, Wansu, Liu, Zhipeng, Fan, Quli, Li, Lin, Huang, Wei
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 10.09.2019
Royal Society of Chemistry
Subjects
Aqueous solutions
Boron
Chemical compounds
chemical reactions
Chemistry
Chemistry, Multidisciplinary
Difluorides
Dyes
Fluorescence
fluorescent dyes
image analysis
Imaging
Nanoparticles
photostability
Physical Sciences
Properties (attributes)
Science & Technology
HIGHLY FLUORESCENT
DYE
WALLED CARBON NANOTUBES
QUANTUM DOTS
BRIGHT
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Summary:The development of new NIR-II fluorophores, particularly those with facile syntheses, high fluorescence quantum yields, and stable and tunable photophysical properties, is challenging. Herein, we report a new class of small molecular NIR-II fluorophores based on aza-dipyrromethene boron difluoride (aza-BODIPY) dyes. We demonstrate promising photophysical properties of these dyes, such as large Stokes shift, superior photostability, and good fluorescence brightness as nanoparticles in aqueous solution. Because of these properties and high resolution and deep penetration NIR-II imaging ability, the aza-BODIPY based dyes show great potential as NIR-II imaging agents.
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ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/C9CC03378E