Long-term treatment of hirsutism: desogestrel compared with cyproterone acetate in oral contraceptives
Effectiveness of 2-year treatment of hirsutism with low estrogen oral contraceptives (OCs) containing nonandrogenic or antiandrogenic progestogen. Evaluation of changes in plasma lipids. Ten patients treated with desogestrel 150μg+30μg ethinyl estradiol, 6 with desogestrel 150μg+50μg ethinyl estradi...
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Published in | Fertility and sterility Vol. 55; no. 5; pp. 877 - 881 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
New York, NY
Elsevier Inc
01.05.1991
Elsevier Science |
Subjects | |
Online Access | Get full text |
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Summary: | Effectiveness of 2-year treatment of hirsutism with low estrogen oral contraceptives (OCs) containing nonandrogenic or antiandrogenic progestogen. Evaluation of changes in plasma lipids.
Ten patients treated with desogestrel 150μg+30μg ethinyl estradiol, 6 with desogestrel 150μg+50μg ethinyl estradiol, 10 with cyproterone acetate 2mg+35μg ethinyl estradiol. Random allocation. Paired comparisons. Control group: 19 normal women, not treated.
Academic tertiary care.
Women with hirsutism (idiopathic and/or polycystic ovary), 24 of 26 completed treatment.
Two-year treatment.
Hirsutism score, plasma testosterone, and lipids.
Initial hirsutism scores (11.8±0.6 SE) declined with treatment (−7.2±0.4, P<0.01) to 4.7±0.6, almost reaching control (3.6±0.3). Initial plasma cholesterol (4.33mmol/L±0.30 SE), similar to control (4.78±0.24), increased slowly over 2years (+2.04±0.34, P<0.01). High-density lipoproteins cholesterol (1.05mmol/L±0.04 SE), similar to control (1.12±0.07), did not change the 1st year and increased at 2years (+0.57±0.11, P<0.01). No differences appeared among treatment groups.
Treatment is very effective, 2years for best results. The OCs tested are equally efficacious. Changes in plasma lipids are of some concern but of difficult interpretation. |
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ISSN: | 0015-0282 1556-5653 |
DOI: | 10.1016/S0015-0282(16)54291-5 |