Non–Vitamin K Antagonist Oral Anticoagulants: The Clinician’s New Challenge

Millions of US patients are prescribed oral anticoagulants. Traditionally, oral anticoagulation was achieved with vitamin K antagonists (VKAs). In recent years, non–VKA oral anticoagulants (NOACs) have emerged that provide an effective and convenient alternative to VKAs. These agents possess very di...

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Bibliographic Details
Published inJournal of Osteopathic Medicine (Online) Vol. 115; no. 10; pp. 612 - 621
Main Authors Yorkgitis, Brian K., Zhang, Jeanette, Rappold, Joseph F.
Format Journal Article
LanguageEnglish
Published United States American Osteopathic Association 01.10.2015
Walter de Gruyter GmbH
Subjects
Administration, Oral
Anticoagulants - administration & dosage
Atrial Fibrillation - complications
Atrial Fibrillation - drug therapy
Humans
Risk Factors
Stroke - etiology
Stroke - prevention & control
Vitamin K
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Summary:Millions of US patients are prescribed oral anticoagulants. Traditionally, oral anticoagulation was achieved with vitamin K antagonists (VKAs). In recent years, non–VKA oral anticoagulants (NOACs) have emerged that provide an effective and convenient alternative to VKAs. These agents possess very different pharmacologic properties from what the medical community has grown accustom to with the VKAs. Thus, a new knowledge base is required for NOACs. One particular challenge with the NOACs is the lack of specific reversal agent, resulting in difficulties correcting the coagulopathy induced by these drugs when needed. A review of the current literature is presented to assist clinicians in gaining knowledge of the NOACs to care for patients.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
ISSN:2702-3648
2702-3648
1945-1997
DOI:10.7556/jaoa.2015.122