Generation of induced pluripotent stem cell lines from helper and cytotoxic T cells of healthy individuals

• Published in: Stem cell research Vol. 69; p. 103113
• Main Authors: Kamaldinov, Timothy, Zhang, Linyi, Wang, Lin, Ye, Zhaohui
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 01.06.2023; Elsevier
• Subjects: Cell Differentiation; Cell Line; Cellular Reprogramming; Embryonic Stem Cells - metabolism; Humans; Induced Pluripotent Stem Cells - metabolism; SOXB1 Transcription Factors - metabolism; T-Lymphocytes, Cytotoxic - metabolism

T lymphocytes are the most abundant mononuclear blood cells and can serve as a source for generating induced pluripotent stem cells (iPSCs) for disease modeling or drug development. Here, we report the derivation of two iPSC lines from CD4+ helper T cells and CD8+ cytolytic T cells, respectively. Th...