Toward an Integrated Research Agenda for Critical Illness in Aging

Aging brings an increased predisposition to critical illness. Patients older than 65 years of age account for approximately half of all intensive care unit (ICU) admissions in the United States, a proportion that is expected to increase considerably with the aging of the population. Emerging researc...

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Published inAmerican journal of respiratory and critical care medicine Vol. 182; no. 8; pp. 995 - 1003
Main Authors Milbrandt, Eric B., Eldadah, Basil, Nayfield, Susan, Hadley, Evan, Angus, Derek C.
Format Journal Article
LanguageEnglish
Published New York, NY American Thoracic Society 15.10.2010
Subjects
Age
Aged
Aging
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Clinical medicine
Critical Care
Critical Care - organization & administration
Health Services for the Aged - organization & administration
Health Services Needs and Demand
Humans
Illnesses
Intensive care
Intensive care medicine
Medical sciences
Miscellaneous
Older people
Patients
Quality of Health Care
Translational Medical Research
United States
United States
United States > US
Human
Intensive care
Senescence
critical care
aging
Elderly
Resuscitation
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Summary:Aging brings an increased predisposition to critical illness. Patients older than 65 years of age account for approximately half of all intensive care unit (ICU) admissions in the United States, a proportion that is expected to increase considerably with the aging of the population. Emerging research suggests that elderly survivors of intensive care suffer significant long-term sequelae, including accelerated age-related functional decline. Existing evidence-based interventions are frequently underused and their efficacy untested in older subjects. Improving ICU outcomes in the elderly will require not only better methods for translating sound science into improved ICU practice but also an enhanced understanding of the underlying molecular, physiological, and pathophysiological interactions of critical illness with the aging process itself. Yet, significant barriers to research for critical illness in aging exist. We review the state of knowledge and identify gaps in knowledge, research opportunities, and barriers to research, with the goal of promoting an integrated research agenda for critical illness in aging.
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Author Disclosure: E.B.M. does not have a financial relationship with a commercial entity that has an interest in the subject of this manuscript. B.E. does not have a financial relationship with a commercial entity that has an interest in the subject of this manuscript. S.N. received $10,001–$50,000 from the NIH/NIA for serving as a scientific advisor for anemia clinical trials and more than $100,001 from the NIH in sponsored grants for investigator-initiated clinical research. E.H. does not have a financial relationship with a commercial entity that has an interest in the subject of this manuscript. D.C.A. does not have a financial relationship with a commercial entity that has an interest in the subject of this manuscript.
Originally Published in Press as DOI: 10.1164/rccm.200904-0630CP on June 17, 2010
Supported by the National Institute on Aging.
ISSN:1073-449X
1535-4970
1535-4970
DOI:10.1164/rccm.200904-0630CP