Application of 3D imaging in the real-time US–CT fusion navigation for minimal invasive tumor therapy

• Published in: International journal for computer assisted radiology and surgery Vol. 10; no. 10; pp. 1651 - 1658
• Main Authors: Wu, Wenbo, Xue, Yingfeng, Wang, Dong, Li, Xiaoguang, Xue, Jin, Duan, Shaobo, Wang, Fang
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2015
• Subjects: Animals; Computer Imaging; Computer Science; Female; Health Informatics; Heart Neoplasms - surgery; Imaging; Liver Neoplasms - surgery; Male; Medicine; Medicine & Public Health; Minimally Invasive Surgical Procedures - methods; Models, Animal; Original Article; Pattern Recognition and Graphics; Radiology; Surgery; Surgery, Computer-Assisted - methods; Swine; Tomography, X-Ray Computed - methods; Vision; 3D image guidance; US–CT fusion navigation; Precise needle targeting; Ultrasound guidance; Minimally invasive treatment
• ISSN: 1861-6410; 1861-6429
• DOI: 10.1007/s11548-015-1224-z

Purpose Image-guided minimally invasive treatment (IG-MIT) has been widely used for local therapy of both benign and malignant tumors. However, precise needle targeting is a very important step in the minimally invasive treatment. Nowadays, minimally invasive treatment is usually performed with the guidance of the two-dimensional (2D) image. The tip of the puncture needle is difficult to place with precise positioning into the three-dimensional (3D) space of the tumor. This study was an experimental ex vivo study in porcine liver and heart samples with internal targets, focusing on the accuracy with the guidance of the real-time 3D imaging using a self-developed real-time ultrasonography and preoperative computed tomography (CT) fusion navigation system for minimal invasive tumor (liver tumor and uterine fibroid) therapy. Methods There are thirty porcine liver samples and thirty porcine heart samples used in the experiments. The average weight of the porcine liver samples was 2216.8 g, and the average weight of the porcine heart samples was 510.5 g. We conducted statistical analysis of the experimental results obtained by five medical students and five interventional radiologists. Results The puncture precision of the needle placement under the guidance of 3D imaging was significantly higher than that of the other groups, and the assistant function is more obvious for medical students than that for interventional radiologists ( p < 0.05 ) . Assistant function of the US–CT fusion imaging is higher than that of the first group too ( p < 0.05 ) . The precision of the puncture with guidance of the 3D imaging was very satisfied in the fact that it was found that there was a mean discrepancy of 2.7 ± 0.7 mm (medical students) and 1.8 ± 0.5 mm (interventional radiologists) in porcine livers and there was a mean discrepancy of 2.7 ± 0.8 mm (medical students) and 1.8 ± 0.5 mm (interventional radiologists) in porcine hearts. Conclusions Experimental results showed that the accuracy of needle targeting can be improved with the guidance of the real-time 3D imaging than that with the guidance of both 2D US images and US–CT fusion images in IG-MIT. Assistant function of 3D imaging is obviously for medical students.