Hemochromatosis Presenting as Acute Liver Failure after Iron Supplementation

To the Editor: Hemochromatosis is an autosomal recessive disorder of iron overload caused by a mutation of the HFE gene on the short arm of chromosome 6. The principal clinical features are diabetes mellitus, cirrhosis, hypogonadism, and cardiac failure, 1 , 2 and the age at clinical presentation is...

Full description

Saved in:
Bibliographic Details
Published inThe New England journal of medicine Vol. 339; no. 4; pp. 269 - 270
Main Authors Roldán, Francisco Pérez, Echenagusia, Ana Amigo, Carro, Pedro González
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 23.07.1998
Subjects
Adult
Female
Ferrous Compounds - adverse effects
Hemochromatosis - complications
Hemochromatosis - pathology
Humans
Liver Failure, Acute - etiology
Online AccessGet full text

Cover

More Information
Summary:To the Editor: Hemochromatosis is an autosomal recessive disorder of iron overload caused by a mutation of the HFE gene on the short arm of chromosome 6. The principal clinical features are diabetes mellitus, cirrhosis, hypogonadism, and cardiac failure, 1 , 2 and the age at clinical presentation is usually 40 years or older. 1 We report a case of acute liver failure after iron supplementation in the setting of unrecognized hemochromatosis. A 29-year-old woman was admitted to the hospital because of a two-day history of jaundice, asthenia, hypercholuria, and hypocholia. The patient had been well until two months before admission, when she . . .
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM199807233390413