Potential antiosteoporotic effect of ginkgo biloba extract via regulation of SIRT1-NF-kB signaling pathway

• Published in: Journal of King Saud University. Science Vol. 32; no. 4; pp. 2513 - 2519
• Main Authors: Li, Zhuoze, Li, Jubao, Zhao, Wanglin, Li, Yan
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.06.2020; Elsevier
• Subjects: Bone loss; Ginkgo biloba extract; NF-kB; Osteoporosis; SIRT1; ALP; ERT; Ginkgo biloba extract; NF-kB; NFkB; HRT; SIRT1; P; Osteoporosis; OC; BMD; Bone loss; Ca; BMSCs; TCM; WHO
• ISSN: 1018-3647
• DOI: 10.1016/j.jksus.2020.04.011

Osteoporosis is bone disorder that happens when too much bone is damaged by the body, causing too little bone or both. As a consequence, bones are brittle and may crack from dropping or sneezing or small bumps in extreme situations. Ginkgo biloba is a Traditional Chinese Medicine (TCM) and commonly used for the treatment of various bone related disease. The current experimental study aimed to scrutinize the anti-osteoporosis effect of Ginkgo biloba and explore the possible mechanism of action. The rats were divided into following groups; Control, Osteoporosis, osteoporosis received ginkgo biloba (25, 50 and 100 mg/kg) and rats were received the treatment after the surgery for 8 weeks. Bone parameters, osteocalcin (OC), alkaline phosphatase (ALP), calcium (Ca), phosphorus (P) and cytokines were estimated. The expression of sirtuin 1 (SIRT1) and nuclear factor kappa B (NF‑κB) were estimated. Dose dependently treatment of ginkgo biloba extract significantly altered the bone parameters such as increase the number of trabecular bone, trabecular bone thickness, connectivity density, ration of BV/TV and decrease the trabecular separation. Ginkgo biloba extract decreased the serum level of ALP, OC, Ca and P at dose dependent manner. ginkgo biloba extract decreased the cytokines at dose dependent manner. Ginkgo biloba extract also reduced the expression of SIRT1 and NF-kB. We can conclude that ginkgo biloba extract showed the anti-osteoporosis effect via activation of SIRT1-NF-kB pathway.