Administration of adipose-derived stem cells enhances vascularity, induces collagen deposition, and dermal adipogenesis in burn wounds

Highlights • ASC delivery increased vascularity and collagen within healing burn wounds. • ASC administration increased adipogenesis within the dermis following burn wounding. • ASCs increased the type III:type I collagen ratio in healing burn wounds.

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Bibliographic Details
Published inBurns Vol. 42; no. 6; pp. 1212 - 1222
Main Authors Bliley, Jacqueline M, Argenta, Anne, Satish, Latha, McLaughlin, Meghan M, Dees, Aaron, Tompkins-Rhoades, Casey, Marra, Kacey G, Rubin, J. Peter
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.09.2016
Subjects
Adipocytes
Adipogenesis
Adipose Tissue - cytology
Adipose-derived stem cell
Animals
Burn wounds
Burns - metabolism
Burns - pathology
Burns - therapy
Collagen
Collagen Type I - metabolism
Collagen Type III - metabolism
Critical Care
Dermis - metabolism
Dermis - pathology
Female
Mice
Mice, Nude
Neovascularization, Physiologic
PPAR gamma - metabolism
Stem Cell Transplantation
Stem Cells - metabolism
Vascularization
Adipocytes
Adipose-derived stem cell
Burn wounds
Collagen
Vascularization
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More Information
Summary:Highlights • ASC delivery increased vascularity and collagen within healing burn wounds. • ASC administration increased adipogenesis within the dermis following burn wounding. • ASCs increased the type III:type I collagen ratio in healing burn wounds.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0305-4179
1879-1409
DOI:10.1016/j.burns.2015.12.007