Antibiofouling polymer interfaces: poly(ethylene glycol) and other promising candidates
Nonspecific protein adsorption and/or microbial adsorption on biomedical materials adversely affects the efficacy of a range of biomedical systems, from implants and biosensors to nanoparticles. To address this problem, antibiofouling polymers can be coated on biomedical devices or built into nanopa...
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| Published in | Polymer chemistry Vol. 6; no. 2; pp. 198 - 212 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
01.01.2015
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Nonspecific protein adsorption and/or microbial adsorption on biomedical materials adversely affects the efficacy of a range of biomedical systems, from implants and biosensors to nanoparticles. To address this problem, antibiofouling polymers can be coated on biomedical devices or built into nanoparticles to confer protein and/or microbial repellent properties. The current review provides an overview of the range of synthetic polymers currently used to this end and explores their biomedical potential. The most widely-used antifouling polymer, poly(ethylene glycol) (PEG) is reviewed alongside several promising alternatives, including zwitterionic polymers, poly(hydroxyfunctional acrylates), poly(2-oxazoline)s, poly(vinylpyrrolidone), poly(glycerol), peptides and peptoids. For each material, notable applications for both nanomedicine and macroscopic surface coatings are highlighted.
This review highlights antibiofouling polymer interfaces with emphasis on the latest developments using poly(ethylene glycol) and the design new polymeric structures. |
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| Bibliography: | Sean Lowe received his Bachelor of Science (Honours) from the University of Queensland and his master's in chemical engineering from the University of Melbourne. Sean completed his thesis work in the Connal Group and received a Melbourne School of Engineering scholarship to undertake work in the lab of Greg Qiao. Currently, Sean works at the University of Melbourne focusing on biologically-inspired materials and polymer science. Luke Connal received a bachelor's of Chemical engineering in 2002 and a PhD in polymer chemistry in 2007 both from the University of Melbourne, Australia. From 2007 to 2009 he completed a post-doctoral position with Frank Caruso. In 2009 he was a Sir Keith Murdoch postdoctoral Fellow at University of California Santa Barbra with Prof. Craig Hawker. In 2013 Luke has returned to the University of Melbourne as a veski Innovation Fellow and Senior Lecturer in the Department of Chemical and Biomolecular Engineering. His research interests lie in the development of bioinspired materials using advanced polymer design, self-assembly and catalysis. Neil O'Brien-Simpson received a BSc (Hons) from Edinburgh Napier University, Scotland in 1992 and worked with I.C.I Chemical and Polymers before completing a PhD in peptide/polymer chemistry and vaccine design in 1997 at the University of Melbourne, Australia as a CRC Vaccine Technology PhD scholar. In 1998, he joined Prof. Eric Reynolds's group as a post-doctoral fellow working on a vaccine towards Chronic Periodontitis. His vaccine work has received the IADR Oral Biology and IADR Hatton awards and has been a CR Roper Fellow at the University of Melbourne. He is currently an A/Professor and since 2004 has been a Project/Program Leader for the Oral Health CRC. His research interests lie in the application of solid phase peptide chemistry in the development of peptide-based vaccines, antimicrobial and anticancer peptides, understanding how the innate immune system interacts with bacteria and how peptide and nanomaterials alter the host cellular responses. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 1759-9954 1759-9962 |
| DOI: | 10.1039/c4py01356e |