Accuracy of a clinical PET/CT vs. a preclinical μPET system for monitoring treatment effects in tumour xenografts

• Published in: European journal of radiology Vol. 82; no. 8; pp. 1318 - 1324
• Main Authors: Palmowski, Karin, Winz, Oliver, Rix, Anne, Bzyl, Jessica, Behrendt, Florian F, Verburg, Frederic A, Mottaghy, Felix M, Palmowski, Moritz
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.08.2013
• Subjects: Angiogenesis Inhibitors - therapeutic use; Animal studies; Animals; Antineoplastic Agents - therapeutic use; Cell Line, Tumor; Drug Monitoring - instrumentation; Drug Monitoring - veterinary; Equipment Design; Equipment Failure Analysis; FDG; Female; Fluorodeoxyglucose F18; Indoles - therapeutic use; Mice; Mice, Nude; Multimodal Imaging - instrumentation; Multimodal Imaging - veterinary; Neoplasms, Experimental - diagnostic imaging; PET/CT; Positron-Emission Tomography - instrumentation; Positron-Emission Tomography - veterinary; Pyrroles - therapeutic use; Radiology; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Tomography, X-Ray Computed - instrumentation; Tomography, X-Ray Computed - veterinary; Treatment Outcome; Tumour treatment; μPET; μPET; FDG; Tumour treatment; Animal studies; PET/CT

Abstract Purpose Small animal imaging is of growing importance for preclinical research and drug development. Tumour xenografts implanted in mice can be visualized with a clinical PET/CT (cPET); however, it is unclear whether early treatment effects can be monitored. Thus, we investigated the accura...