Generation of an integration-free induced pluripotent stem cell line, FJMUUHi002-A, from a Rett syndrome patient with a heterozygous mutation p. R133C in MeCP2

• Published in: Stem cell research Vol. 74; p. 103268
• Main Authors: Guo, Yu, Li, Jiaqi, Xie, Wenyi, Huang, Huaping, Li, Jin-Jing, Lin, Wanhui, Lu, Ying-Qian
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 01.02.2024; Elsevier
• Subjects: Cell Differentiation; Cell Line; Child; Female; Humans; Induced Pluripotent Stem Cells - metabolism; Leukocytes, Mononuclear; Mutation - genetics; Rett Syndrome - genetics

The human iPS cell line, hiPS-RTT (FJMUi002-A), is derived from peripheral blood mononuclear cells (PBMCs) from a 12-year-old female RTT patient carrying a heterozygous p. R133C (c.397C > T) mutation in the MeCP2 gene. The hiPS-RTT cell line was generated by non-integrative reprogramming vectors...