Red fluorescent probes for real-time imaging of the cell cycle by dynamic monitoring of the nucleolus and chromosome

Two cationic molecular rotors, 1 and 2 , capable of real-time cell-cycle imaging by specifically dynamic monitoring of nucleolus and chromosome changes were developed. A further study shows that fluorescence enhancements in the nucleolus and chromosome are attributed to a combination effect of inter...

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Published inChemical communications (Cambridge, England) Vol. 54; no. 21; pp. 2635 - 2638
Main Authors Wang, Kang-Nan, Chao, Xi-Juan, Liu, Bing, Zhou, Dan-Jie, He, Liang, Zheng, Xiao-Hui, Cao, Qian, Tan, Cai-Ping, Zhang, Chen, Mao, Zong-Wan
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 2018
Royal Society of Chemistry
Subjects
Cell cycle
cell nucleolus
chemical compounds
chemical reactions
Chemistry
Chemistry, Multidisciplinary
chromosomes
fluorescence
Fluorescent indicators
image analysis
molecular rotors
Monitoring
nucleic acids
Physical Sciences
Real time
Rotors
Science & Technology
VISCOSITY
RNA
LIVE CELLS
LIFETIME
LIVING CELLS
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Summary:Two cationic molecular rotors, 1 and 2 , capable of real-time cell-cycle imaging by specifically dynamic monitoring of nucleolus and chromosome changes were developed. A further study shows that fluorescence enhancements in the nucleolus and chromosome are attributed to a combination effect of interaction with nucleic acid and high condensation of the nucleolus and chromosome.
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ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/C8CC00256H