Polymorphism in glutathione S-transferase P1 is associated with susceptibility to Plasmodium vivax malaria compared to P. falciparum and upregulates the GST level during malarial infection

• Published in: Free radical biology & medicine Vol. 49; no. 11; pp. 1746 - 1754
• Main Authors: Sohail, Mohammad, Kumar, Ritesh, Kaul, Asha, Arif, Ehtesham, Kumar, Sanjit, Adak, Tridibes
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2010
• Subjects: Adult; Amino Acid Substitution - genetics; Biomarkers - analysis; Biomarkers - metabolism; Case-Control Studies; Disease Progression; DNA Mutational Analysis; Female; Free radicals; Genetic Association Studies; Genetic Predisposition to Disease; Glutathione - metabolism; Glutathione S-Transferase pi - genetics; Glutathione S-Transferase pi - metabolism; GST; GSTP1; Humans; Malaria, Falciparum - genetics; Malaria, Falciparum - metabolism; Malaria, Vivax - genetics; Malaria, Vivax - metabolism; Male; P. falciparum malaria; P. vivax malaria; Plasmodium falciparum; Plasmodium vivax; Polymorphism; Polymorphism, Single Nucleotide - physiology; Up-Regulation; P. falciparum malaria; Free radicals; DTNB; JNK; GSTP1; GST; CDNB; GPX; SNP; ROS; P. vivax malaria; GSH; Polymorphism

Glutathione S-transferase P1 (GSTP1) is a member of the GST superfamily, which has well-established multiple roles in various infectious and parasitic diseases. The genetic regulation of GSTP1 has been extensively studied. Thus, its biological significance and disease association prompted us to inve...