Aggregatibacter actinomycetemcomitans biofilm can be inactivated by methylene blue-mediated photodynamic therapy

• Published in: Photodiagnosis and photodynamic therapy Vol. 12; no. 1; pp. 131 - 135
• Main Authors: Alvarenga, Letícia Heineck, Prates, Renato Araujo, Yoshimura, Tania Mateus, Kato, Ilka Tiemy, Suzuki, Luis Cláudio, Ribeiro, Martha Simões, Ferreira, Luis Rodolfo, Pereira, Sílvio Antônio dos Santos, Martinez, Elizabeth Ferreira, Saba-Chujfi, Eduardo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2015
• Subjects: Aggregatibacter actinomycetemcomitans - drug effects; Aggregatibacter actinomycetemcomitans - physiology; Antimicrobial photodynamic chemotherapy; Antimicrobial photodynamic inactivation; Apoptosis - drug effects; Apoptosis - radiation effects; Biofilms - drug effects; Biofilms - growth & development; Biofilms - radiation effects; Cell Survival - drug effects; Cell Survival - radiation effects; Dose-Response Relationship, Radiation; Hematology, Oncology and Palliative Medicine; Internal Medicine; Light; Methylene Blue - administration & dosage; Periodontal disease; Periodontitis; Photochemotherapy - methods; Photosensitizer; Photosensitizing Agents - therapeutic use; Red laser; Red laser; Antimicrobial photodynamic inactivation; Periodontal disease; Periodontitis; Photosensitizer; Antimicrobial photodynamic chemotherapy
• ISSN: 1572-1000; 1873-1597
• DOI: 10.1016/j.pdpdt.2014.10.002

Highlights • We investigated Aggregatibacter actinomycetemcomitans biofilm following PDT. • PDT needs more than 1 min of irradiation to be effective against bacterial biofilm. • PDT with methylene blue and red laser is a promising therapy for periodontitis. • PDT can disrupt bacterial biofilm structure.