The potential of biomarkers in psychiatry: focus on proteomics

The etiology and pathogenesis of many psychiatric disorders are unclear with many signaling pathways and complex interactions still unknown. Primary information provided from gene expression or brain activity imaging experiments is useful, but can have limitations. There is a current effort focusing...

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Published inJournal of Neural Transmission Vol. 122; no. Suppl 1; pp. 9 - 18
Main Authors Sokolowska, Izabela, Ngounou Wetie, Armand G., Wormwood, Kelly, Thome, Johannes, Darie, Costel C., Woods, Alisa G.
Format Journal Article
LanguageEnglish
Published Vienna Springer Vienna 01.08.2015
Subjects
Biomarkers - metabolism
Humans
Medicine
Medicine & Public Health
Mental Disorders - metabolism
Neurology
Neurosciences
Proteomics
Psychiatry
Psychiatry and Preclinical Psychiatric Studies - Review article
Biomarkers
Psychiatry
Mass spectrometry
Proteomics
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Summary:The etiology and pathogenesis of many psychiatric disorders are unclear with many signaling pathways and complex interactions still unknown. Primary information provided from gene expression or brain activity imaging experiments is useful, but can have limitations. There is a current effort focusing on the discovery of diagnostic and prognostic proteomic potential biomarkers for psychiatric disorders. Despite this work, there is still no biological diagnostic test available for any mental disorder. Biomarkers may advance the care of psychiatric illnesses and have great potential to knowledge of psychiatric disorders but several drawbacks must be considered. Here, we describe the potential of proteomic biomarkers for better understanding and diagnosis of psychiatric disorders and current putative biomarkers for schizophrenia, depression, autism spectrum disorder and attention deficit/hyperactivity disorder.
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ISSN:0300-9564
1435-1463
DOI:10.1007/s00702-013-1134-6