Gastric calcifying fibrous tumor removed by endoscopic submucosal dissection

The World Health Organization describes calcifying fibrous tumors(CFTs) as rare, benign lesions characterized by hypocellular, densely hyalinized collagenization with lymphoplasmacytic infiltration. These tumors rarely involve the gastrointestinal(GI) tract. A routine endoscopic upper gastrointestin...

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Published inWorld journal of gastrointestinal endoscopy Vol. 5; no. 9; pp. 457 - 460
Main Authors Ogasawara, Naotaka, Izawa, Shinya, Mizuno, Mari, Tanabe, Atsushi, Ozeki, Tomonori, Noda, Hisatsugu, Takahashi, Emiko, Sasaki, Makoto, Yokoi, Toyoharu, Kasugai, Kunio
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Co., Limited 16.09.2013
Subjects
Calcifying
Case Report
dissection
Endoscopic
fibrous
submucosal
tumor
ultrasonography
Endoscopic submucosal dissection
Submucosal tumor
Calcifying fibrous tumor
Endoscopic ultrasonography
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Summary:The World Health Organization describes calcifying fibrous tumors(CFTs) as rare, benign lesions characterized by hypocellular, densely hyalinized collagenization with lymphoplasmacytic infiltration. These tumors rarely involve the gastrointestinal(GI) tract. A routine endoscopic upper gastrointestinal screen detected a 10-mm submucosal tumor(SMT) in the lesser curvature of the lower corpus of the stomach of an apparently healthy, 37-year-old woman with no history of Helicobacter pylori infection. Endoscopic ultrasonography(EUS) localized the internally isoechoic, homogeneous SMT mainly within the submucosa. Malignancy was ruled out using endoscopic submucosal dissection(ESD). A pathological examination confirmed complete resection of the SMT, and defined a hypocellular, spindle-cell tumor with a densely hyalinized, collagenous matrix, scattered lymphoplasmacytic aggregates as well as a few psammomatous, dystrophic calcified foci. The mass was immunohistochemically positive for vimentin and negative for CD117(c-kit protein), CD34, desmin, smooth muscle actin(SMA) and S100. Therefore, the histological findings were characteristic of a CFT. To date, CFT resection by ESD has not been described. This is the first case report of a gastric calcifying fibrous tumor being completely resected by ESD after endoscopic ultrasonography.
Bibliography:Naotaka Ogasawara;Shinya Izawa;Mari Mizuno;Atsushi Tanabe;Tomonori Ozeki;Hisatsugu Noda;Emiko Takahashi;Makoto Sasaki;Toyoharu Yokoi;Kunio Kasugai;Department of Gastroenterology, Aichi Medical University School of Medicine;Department of Pathology,Aichi Medical University School of Medicine
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Author contributions: Ogasawara N, Izawa S and Tanabe A performed endoscopic submucosal resection of the submucosal tumor; Mizuno M, Ozeki T and Noda H managed the patient’s condition during hospitalization; Takahashi E and Yokoi T pathologically diagnosed the SMT as a gastric calcifying fibrous tumor; Ogasawara N, Sasaki M and Kasugai K wrote the manuscript.
Correspondence to: Naotaka Ogasawara, MD, Department of Gastroenterology, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan. nogasa@aichi-med-u.ac.jp
Telephone: +81-561-623311 Fax: +81-561-621508
ISSN:1948-5190
1948-5190
DOI:10.4253/wjge.v5.i9.457