Neurological manifestations of coinfection with HIV and human T-lymphotropic virus type 1

• Published in: AIDS (London) Vol. 26; no. 4; pp. 521 - 523
• Main Authors: SILVA, Marcus T. T, NEVES, Elizabeth S, GRINSZTEJN, Beatriz, MELO ESPINDOLA, Otavio De, SCHOR, Doris, ARAUJO, Abelardo
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 20.02.2012
• Subjects: AIDS/HIV; Antiretroviral Therapy, Highly Active; Biological and medical sciences; CD4 Lymphocyte Count; Coinfection; Deltaretrovirus Antibodies - blood; Female; Hepatitis C Antibodies - blood; Hepatitis C virus; HIV Infections - complications; HIV Infections - physiopathology; HTLV-II Infections - complications; HTLV-II Infections - physiopathology; Human immunodeficiency virus; Human T-lymphotropic virus; Human T-lymphotropic virus 1 - pathogenicity; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infectious diseases; Male; Medical sciences; Middle Aged; Odds Ratio; Peripheral Nervous System Diseases - physiopathology; Peripheral Nervous System Diseases - virology; Spinal Cord Diseases - virology; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viral Load; Immunopathology; Mixed infection; Deltaretrovirus; Retroviridae; AIDS; Nervous system; Immune deficiency; Lentivirus; Infection; Virus; Viral disease; Human immunodeficiency virus; HTLV-I virus
• ISSN: 0269-9370; 1473-5571
• DOI: 10.1097/QAD.0b013e32834c4a3e

HIV-individuals are at risk for human T-lymphotropic virus (HTLV) coinfection and neurological diseases. Little is known about the impact of HAART among coinfected patients. In this study, 47 out of 428 HIV individuals were coinfected with HTLV (10.9%). Coinfection was an independent variable associated with neurological outcome (odds ratio 8.73). Coinfection was associated with myelopathy [chi square (X(2)) = 93, P < 0.001], peripheral neuropathy (X(2) = 6.5, P = 0.01), and hepatitis C virus infection (X(2) = 36.5, P < 0.001). HAART did not appear to protect against neurological diseases and had no impact on HTLV proviral load.