Mechanisms of hepatic ischemia-reperfusion injury and protective effects of nitric oxide

Hepatic ischemia-reperfusion injury(IRI) is a patho-physiological event post liver surgery or transplantation and significantly influences the prognosis of liver func-tion. The mechanisms of IRI remain unclear, and effec-tive methods are lacking for the prevention and therapy of IRI. Several factors...

Full description

Saved in:
Bibliographic Details
Published inWorld journal of gastrointestinal surgery Vol. 6; no. 7; pp. 122 - 128
Main Author Guan, Lian-Yue
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 27.07.2014
Subjects
cells
Chemokine
Cyto-kine
injury
Ischemia-reperfusion
Kupffer
Liver
Mitochondria
Nitric
oxide
Review
Chemokine
Ischemia-reperfusion injury
Mitochondria
Liver
Nitric oxide
Cytokine
Kupffer cells
Online AccessGet full text

Cover

More Information
Summary:Hepatic ischemia-reperfusion injury(IRI) is a patho-physiological event post liver surgery or transplantation and significantly influences the prognosis of liver func-tion. The mechanisms of IRI remain unclear, and effec-tive methods are lacking for the prevention and therapy of IRI. Several factors/pathways have been implicated in the hepatic IRI process, including anaerobic metabo-lism, mitochondria, oxidative stress, intracellular cal-cium overload, liver Kupffer cells and neutrophils, and cytokines and chemokines. The role of nitric oxide(NO)in protecting against liver IRI has recently been report-ed. NO has been found to attenuate liver IRI through various mechanisms including reducing hepatocellular apoptosis, decreasing oxidative stress and leukocyte adhesion, increasing microcirculatory flow, and enhanc-ing mitochondrial function. The purpose of this review is to provide insights into the mechanisms of liver IRI, indicating the potential protective factors/pathways that may help to improve therapeutic regimens for control-ling hepatic IRI during liver surgery, and the potential therapeutic role of NO in liver IRI.
Bibliography:Lian-Yue Guan;Pei-Yao Fu;Pei-Dong Li;Zhuo-Nan Li;Hong-Yu Liu;Min-Gang Xin;Wei Li;Department of Hepatobiliary-Pancreatic Surgery, Third Hospital (China-Japan Union Hospital) of Jilin University;Departments of Anesthesiology, Third Hospital (China-Japan Union Hospital) of Jilin University
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
Correspondence to: Wei Li, MD, PhD, Department of Hepatobiliary-Pancreatic Surgery, Third Hospital (China-Japan Union Hospital) of Jilin University, 126 Xiantai Street, Changchun 130033, Jilin Province, China. weili888@hotmail.com
Author contributions: Guan LY and Fu PY contributed equally to the paper; Guan LY primarily drafted the article; Fu PY performed the intensive revision and drew the two figures; Li PD drafted the nitric oxide portion of the manuscript; Li ZN, Liu HY and Xin MG conducted the data collection and interpretation, selected the references, and drafted the discussion; Li W contributed to the concept design, critical revision and finalization of the manuscript.
Telephone: +86-431-89876816 Fax: +86-431-84641026
ISSN:1948-9366
1948-9366
DOI:10.4240/wjgs.v6.i7.122