Safety evaluation of excessive intake of calcium-fortified fish sausage to prevent osteoporosis in humans

• Published in: Nihon Shokuhin Kagaku Kōgaku kaishi Vol. 57; no. 4
• Main Authors: Murota, I., Maruha Nichiro Holdings Inc., Tsukuba, Ibaraki (Japan). Central Research Inst, Baba, T, Shimada, M, Sato, N
• Format: Journal Article
• Language: Japanese
• Published: 01.01.2010
• Subjects: ANALISIS; ANALYSE; ANALYSIS; APPORT ALIMENTAIRE RECOMMANDE; BONE DISEASES; CALCIO; CALCIUM; COMPLEMENTATION; EATING DISORDERS; ENFERMEDADES OSEAS; ENRIQUECIMIENTO DE LOS ALIMENTOS; FISH; FOOD ENRICHMENT; GENERO HUMANO; GENRE HUMAIN; http://www.fao.org/aos/agrovoc#c_1196; http://www.fao.org/aos/agrovoc#c_15903; http://www.fao.org/aos/agrovoc#c_3018; http://www.fao.org/aos/agrovoc#c_34090; http://www.fao.org/aos/agrovoc#c_4586; http://www.fao.org/aos/agrovoc#c_49928; http://www.fao.org/aos/agrovoc#c_6732; http://www.fao.org/aos/agrovoc#c_6824; http://www.fao.org/aos/agrovoc#c_8879; http://www.fao.org/aos/agrovoc#c_996; MANKIND; OSTEOPATHIE; PESCADO; POISSON (ALIMENT); RACION DIETETICA RECOMENDADA; RECOMMENDED DIETARY ALLOWANCES; SAFETY; SALCHICHA; SAUCISSE; SAUSAGES; SECURITE; SEGURIDAD; TRASTORNOS ALIMENTICIOS; TROUBLE ALIMENTAIRE
• ISSN: 1341-027X
• DOI: 10.3136/nskkk.57.163

This study attempted to clarify the safety of excessive intake (400 mg) of calcium-fortified fish sausage, a special health food in Japan, in the prevention of osteoporosis. Safety was evaluated based on an open-label human trial in which 20 healthy subjects took 3 times the recommend amount of fish sausages a day for 4 weeks. Adverse events were assessed, and physical measurements, laboratory assessment and nutrition were analyzed. During the 4-week safety evaluation, no clinical changes were found in any of the subjects. Thus the daily intake of fish sausage appears to be safe as a means to obtain the daily requirements of calcium.