Loss of Temporal Inhibition of Nociceptive Information Is Associated With Aging and Bodily Pain

• Published in: The journal of pain Vol. 18; no. 12; pp. 1496 - 1504
• Main Authors: Naugle, Kelly M., Cruz-Almeida, Yenisel, Fillingim, Roger B., Riley, Joseph L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2017
• Subjects: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; aging; Aging - physiology; Analgesia; Female; Humans; Male; Middle Aged; Nociception - physiology; Nociceptive Pain - physiopathology; offset analgesia; older adults; Pain inhibition; Pain Measurement; Physical Stimulation; Time Factors; Young Adult; older adults; aging; offset analgesia; Pain inhibition
• ISSN: 1526-5900; 1528-8447; 1528-8447
• DOI: 10.1016/j.jpain.2017.08.003

•Older adults showed reduced offset analgesia compared with younger adults.•No sex differences in offset analgesia were evident in any age group.•A reduction stimuli as small as .4°C resulted in significant offset analgesia.•Reduced offset analgesia was associated with pain in daily life for all age groups. An age-related decline in endogenous pain inhibitory processes likely places older adults at an increased risk for chronic pain. Limited research indicates that older adults may be characterized by deficient offset analgesia, an inhibitory temporal sharpening mechanism that increases the detectability of minor decreases in noxious stimulus intensity. The primary purpose of the study was to examine age differences in offset analgesia in community-dwelling younger, middle-aged, and older adults. An additional aim of the study was to determine whether the magnitude of offset analgesia predicted self-reported bodily pain. Eighty-seven younger adults, 42 middle-aged adults, and 60 older adults completed 4 offset analgesia trials and 3 constant temperature trials in which a noxious heat stimulus was applied to the volar forearm for 40 seconds. The offset trials consisted of 3 continuous phases: an initial 10-second painful stimulus, either a 1.0°C or .4°C increase in temperature from the initial 10-second painful stimulus for 10 seconds, and either a 1.0°C or .4°C decrease back to the initial testing temperature for 20 seconds. During each trial, subjects rated pain intensity continuously using an electronic visual analog scale (0–100). All subjects also completed the Short-Form Health Survey-36 including the Bodily Pain subscale. The results indicated that older and middle-aged adults showed reduced offset analgesia compared with younger adults in the 1.0°C and .4°C offset trials. Furthermore, the magnitude of offset analgesia predicted self-reported bodily pain, with those exhibiting reduced offset analgesia reporting greater bodily pain. Dysfunction of this endogenous inhibitory system could increase the risk of developing chronic pain for middle-aged and older adults. Older and middle-aged adults showed reduced offset analgesia compared with younger adults. The significant association between reduced offset analgesia and pain in daily life supports the notion that pain modulatory deficits are associated with not just a chronic pain condition but with the experience of pain in general.