Distribution-based estimates of Minimum Clinically Important Difference in Cognition, Arm Function and Lower Body Function after Slow Release-Fampridine Treatment of Patients with Multiple Sclerosis

Abstract Objective: To provide distribution-based estimates of the minimal clinical important difference (MCID) after slow release fampridine treatment on cognition and functional capacity in people with MS (PwMS). Method MCID values were determined after SR-Fampridine treatment in 105 PwMS. Testing...

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Published inMultiple sclerosis and related disorders Vol. 7; pp. 58 - 60
Main Authors Jensen, HB, Mamoei, Sepehr, Ravnborg, M, Dalgas, U, Stenager, E
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.05.2016
Subjects
4-Aminopyridine - therapeutic use
Arm - physiopathology
Axonal loss
Change
Cognition - drug effects
Demyelination
Disability Evaluation
Exercise Test
Female
Humans
Male
MCID
Middle Aged
Minimal clinically important difference
Motor Activity - drug effects
Motor Activity - physiology
Multiple sclerosis
Multiple Sclerosis - drug therapy
Multiple Sclerosis - physiopathology
Multiple Sclerosis - psychology
Neurology
Potassium Channel Blockers - therapeutic use
Reference Values
Rehabilitation
Walking - physiology
Multiple Sclerosis
rehabilitation
MCID
demyelination
change
minimal clinically important difference
axonal loss
Multiple sclerosis
Demyelination
Change
Rehabilitation
Axonal loss
Minimal clinically important difference
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Summary:Abstract Objective: To provide distribution-based estimates of the minimal clinical important difference (MCID) after slow release fampridine treatment on cognition and functional capacity in people with MS (PwMS). Method MCID values were determined after SR-Fampridine treatment in 105 PwMS. Testing included the Timed 25 Foot Walk (T25FW), the Symbol Digit Modalities Test (SDMT), the Six Spot Step Test (SSST), the 9-Hole-Peg-Test (9-HPT), and the 5-Time-Sit-To-Stand test (5-STS). Results: MCID values: T25FW 17.8% (9.1-17.8), SDMT 17.1% (9.2-17.1), SSST 16.7% (8.5-16.7), 9-HPT 15.3% (0-15.3), and 5-STS 34.6% (16.9-34.6). Conclusion: This study presents distribution-based estimates of MCID values for the SSST, the 9-HPT, and the 5-STS and confirms MCID estimates for the T25FW and the SDMT.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:2211-0348
2211-0356
DOI:10.1016/j.msard.2016.03.007