Laser-induced autofluorescence spectroscopy: Can it be of importance in detection of bladder lesions?

• Published in: Photodiagnosis and photodynamic therapy Vol. 12; no. 1; pp. 76 - 83
• Main Authors: Aboumarzouk, Omar, MBChB, PhD, Valentine, Ronan, Buist, Ron, Ahmad, Sarfraz, Nabi, Ghulam, Eljamel, Sam, Moseley, Harry, Kata, Slawomir Grzegorz
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2015
• Subjects: Aged; Aged, 80 and over; Autofluorescence; Bladder cancer; Hematology, Oncology and Palliative Medicine; Humans; Image Interpretation, Computer-Assisted - methods; Internal Medicine; Laser; Lasers; Middle Aged; Optical biopsy; Optical Imaging - methods; Optical spectrometry; Photosensitizing Agents - analysis; Protoporphyrins - analysis; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence - methods; Spectroscopy; Urinary Bladder Neoplasms - chemistry; Urinary Bladder Neoplasms - diagnosis; carcinoma in situ; PDT; Optical spectrometry; Spectroscopy; photodynamic diagnostic; protoporphyrin IX; ultrasonography; photodynamic therapy; Autofluorescence; PPIX; area under the curve; IQR; interquartile range; CIS; optical biopsy; Bladder cancer; AUC; narrow band imaging; OB; NBI; PD; Laser; US; Optical biopsy
• ISSN: 1572-1000; 1873-1597
• DOI: 10.1016/j.pdpdt.2014.12.003

Highlights • There were significant statistical differences between the median AUC calculations for the benign and cancerous tissue. • There were significant statistical differences between the median wavelengths for the benign and cancerous tissue. • There were significant statistical differences between the fluorescence ratios between the benign and cancerous tissue. • There seems to be a role for optical spectroscopy in verifying bladder lesions.