Hormone replacement therapy and intraocular pressure

• Published in: Maturitas Vol. 28; no. 1; pp. 55 - 58
• Main Authors: Sator, Michael O., Joura, Elmar A., Frigo, Peter, Kurz, Christine, Metka, Markus, Hommer, Anton, Huber, Johannes C.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.09.1997; Elsevier Science
• Subjects: Biological and medical sciences; Estrogen Replacement Therapy; Female; Gynecology. Andrology. Obstetrics; Hormone replacement therapy; Humans; Intraocular pressure; Intraocular Pressure - drug effects; Medical sciences; Menopause; Middle Aged; Nitric oxide; Prospective Studies; Puberal and climacteric disorders (male and female); Time Factors; Hormone replacement therapy; Menopause; Nitric oxide; Intraocular pressure; Human; Eye disease; Chemotherapy; Replacement therapy; Glaucoma (eye); Female; Sex steroid hormone
• ISSN: 0378-5122; 1873-4111
• DOI: 10.1016/S0378-5122(97)00060-1

Objectives: To evaluate the effect of hormone replacement therapy (HRT) on intraocular pressure (IOP) in menopausal women. Methods: The IOP of 25 white menopausal women without an abnormal ophthalmologic history was measured before and during HRT regimen. IOP fluctations were recorded before and 1, 4, and 12 weeks after the beginning of HRT. These measurements were obtained according to a standardized time schedule (08:00, 12:00, 16:00, and 19:00 h). Results: The mean IOP in the left eye decreased from 16.2 ± 2.4 mmHg before therapy to 14.0 ± 2.1 mmHg after 12 weeks of therapy ( P<0.001). In the right eye, whose IOP was at 15.3 ± 2.3 mmHg before therapy there was a decrease to 14.0 ± 1.9 mmHg after 12 weeks of therapy ( P<0.001). Conclusion: Hormone replacement therapy has a positive effect on IOP in menopausal women.