Potential of microneedles in enhancing delivery of photosensitising agents for photodynamic therapy

Highlights • Photodynamic therapy is an effective treatment method for certain skin lesions. • Topical photodynamic therapy is preferable but its applications are limited. • Microneedles consist of micron-sized projections amassed on a base-plate. • Microneedles enhance efficacy of photodynamic ther...

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Bibliographic Details
Published inPhotodiagnosis and photodynamic therapy Vol. 11; no. 4; pp. 459 - 466
Main Authors Kearney, Mary-Carmel, Brown, Sarah, McCrudden, Maelíosa T.C, Brady, Aaron J, Donnelly, Ryan F
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.12.2014
Subjects
Equipment Design
Equipment Failure Analysis
Feasibility Studies
Hematology, Oncology and Palliative Medicine
Internal Medicine
Microfluidics - instrumentation
Microinjections - instrumentation
Microneedle
Miniaturization
Needles
Photochemotherapy - instrumentation
Photodynamic therapy
Photosensitiser
Photosensitizing Agents - administration & dosage
Photosensitizing Agents - therapeutic use
Preformed photosensitisers
Photodynamic therapy
Photosensitiser
Microneedle
Preformed photosensitisers
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Summary:Highlights • Photodynamic therapy is an effective treatment method for certain skin lesions. • Topical photodynamic therapy is preferable but its applications are limited. • Microneedles consist of micron-sized projections amassed on a base-plate. • Microneedles enhance efficacy of photodynamic therapy. • Deeper skin lesions can be treated with microneedles and photodynamic therapy.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1572-1000
1873-1597
DOI:10.1016/j.pdpdt.2014.09.003