Cell-mediated immunity: delayed-type hypersensitivity and cytotoxic responses are mediated by different T-cell subclasses

Cell-mediated immunity includes both the generation of cytotoxic cells and initiation of delayed-type hypersensitivity (DTH). The resting T-cell population, before stimulation by antigen, already contains cells of the Lyl subclass that are programmed to initiate DTH (and helper function) but not cyt...

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Bibliographic Details
Published inThe Journal of experimental medicine Vol. 143; no. 6; pp. 1534 - 1539
Main Authors Huber, B, Devinsky, O, Gershon, R K, Cantor, H
Format Journal Article
LanguageEnglish
Published United States The Rockefeller University Press 01.06.1976
Subjects
Animals
Antigens - administration & dosage
Cell Separation
Cytotoxicity Tests, Immunologic
Hypersensitivity, Delayed - immunology
Immunity, Cellular
Isoantigens
Mice
Mice, Inbred C57BL
Radiation Chimera
Surface Properties
T-Lymphocytes - immunology
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Summary:Cell-mediated immunity includes both the generation of cytotoxic cells and initiation of delayed-type hypersensitivity (DTH). The resting T-cell population, before stimulation by antigen, already contains cells of the Lyl subclass that are programmed to initiate DTH (and helper function) but not cytotoxic responses, as well as Ly23 cells which can generate killer activity (and suppressive function) but not DTH. The central implication of these findings is that the broad division between humoral and cell-mediated immune responses does not precisely correspond to the division of labor among T-cell subclasses. The relative contribution of DTH-competent Lyl cells and cytotoxic Ly23 cells to the classical homograft response remains to be determined.
ISSN:0022-1007
1540-9538
DOI:10.1084/jem.143.6.1534