Environmental enrichment modulates glucocorticoid receptor expression and reduces anxiety in Indian field male mouse Mus booduga through up-regulation of microRNA-124a

Highlights • Standard condition (short-term/long-term) induces anxiety-like behavior in field mouse. • Enriched condition (EC) decreases anxiety-like behavior. • Expression of DICER and AGO-2 are up regulated in EC mice. • EC reduces the expression of GR through up regulation of microRNA-124a. • EC...

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Bibliographic Details
Published inGeneral and comparative endocrinology Vol. 199; pp. 26 - 32
Main Authors Durairaj, Ragu Varman, Koilmani, Emmanuvel Rajan
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.04.2014
Subjects
3' Untranslated Regions - genetics
Animals
Anxiety
Anxiety - genetics
Argonaute Proteins - genetics
Argonaute Proteins - metabolism
Arvicolinae - metabolism
Behavior, Animal
Darkness
Endocrinology & Metabolism
Enriched condition
Environment
Glucocorticoid receptor
Housing, Animal
India
Light/dark box
Male
Mice
MicroRNAs - genetics
MicroRNAs - metabolism
miR-124a
Protein Binding - genetics
Receptors, Glucocorticoid - genetics
Receptors, Glucocorticoid - metabolism
Ribonuclease III - genetics
Ribonuclease III - metabolism
RNA, Messenger - genetics
RNA, Messenger - metabolism
Up-Regulation - genetics
India
miR-124a
Anxiety
Enriched condition
Light/dark box
Glucocorticoid receptor
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Summary:Highlights • Standard condition (short-term/long-term) induces anxiety-like behavior in field mouse. • Enriched condition (EC) decreases anxiety-like behavior. • Expression of DICER and AGO-2 are up regulated in EC mice. • EC reduces the expression of GR through up regulation of microRNA-124a. • EC effectively reverse the effect of short term standard condition.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2014.01.005