Generation of nine induced pluripotent stem cell lines from six young children with autism spectrum disorder and three matched control subjects from the Qatari population

Autism spectrum disorder (ASD) is a complex developmental disorder characterized by challenges with social interactions and restricted/repetitive behaviors. Here, we recruited nine Qatari children of Arab ethnicity (males, aged 2–4 years), including six ASD subjects (n = 3 mild-to-moderate ASD and n...

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Published inStem cell research Vol. 79; p. 103470
Main Authors Ltaief, Samia M., Elsayed, Ahmed K., Al-Shammari, Abeer R.
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 01.09.2024
Elsevier
Subjects
Autism Spectrum Disorder
Case-Control Studies
Cell Differentiation
Cell Line
Child, Preschool
Female
Humans
Induced Pluripotent Stem Cells - cytology
Induced Pluripotent Stem Cells - metabolism
Male
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Summary:Autism spectrum disorder (ASD) is a complex developmental disorder characterized by challenges with social interactions and restricted/repetitive behaviors. Here, we recruited nine Qatari children of Arab ethnicity (males, aged 2–4 years), including six ASD subjects (n = 3 mild-to-moderate ASD and n = 3 severe ASD) and three control subjects. We generated induced pluripotent stem cell (iPSC) lines from PBMC samples of these subjects using non-integrating Sendai viral vectors. These iPSC lines were fully characterized and exhibited pluripotency characteristics, normal karyotypes, and trilineage differentiation potential. These iPSC lines provide valuable cell models for understanding ASD pathophysiology and developing new therapeutics for ASD.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1873-5061
1876-7753
1876-7753
DOI:10.1016/j.scr.2024.103470