Pathologic yawning in neuromyelitis optica spectrum disorders

Abstract Introduction Brainstem, hypothalamic and cerebral symptoms may occur in neuromyelitis optica spectrum disorders (NMOSD). However, pathologic yawning has not been previously described in NMOSD patients. Patients and methods Nine AQP4-IgG seropositive NMOSD patients experienced excessive yawn...

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Published inMultiple sclerosis and related disorders Vol. 3; no. 4; pp. 527 - 532
Main Authors Lana-Peixoto, Marco A, Callegaro, Dagoberto, Talim, Natália, Talim, Livia E, Pereira, Samira A, Campos, Gilberto Belisário
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.07.2014
Subjects
Brainstem lesions
Hiccups
Hypothalamic lesions
Nausea/vomiting
Neurology
Neuromyelitis optica spectrum disorders
Pathologic yawning
Pathologic yawning
Hiccups
Nausea/vomiting
Hypothalamic lesions
Neuromyelitis optica spectrum disorders
Brainstem lesions
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Summary:Abstract Introduction Brainstem, hypothalamic and cerebral symptoms may occur in neuromyelitis optica spectrum disorders (NMOSD). However, pathologic yawning has not been previously described in NMOSD patients. Patients and methods Nine AQP4-IgG seropositive NMOSD patients experienced excessive yawning not related to sleep deprivation or fatigue. Results Patients were female, aged 19–57 years (median, 39 years) at disease onset. Excessive yawning spells were the presenting symptom of the disease in five patients, lasted 2–16 weeks, and usually occurred in association with nausea, vomiting and hiccups. Brain MRI was abnormal in all patients and most frequently showed brainstem and hypothalamic lesions. Conclusion Pathologic yawning may be a neglected although not a rare symptom in NMOSD.
Bibliography:ObjectType-Article-1
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ISSN:2211-0348
2211-0356
DOI:10.1016/j.msard.2014.04.002