Uveal melanoma

Uveal melanoma is the most common primary intraocular malignancy in adults. It is associated with a high rate of distant tumor spread and consequent mortality. Unlike retinoblastoma, for which treatment advances over the last few decades have resulted in a dramatic improvement in survival, outcomes...

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Bibliographic Details
Published inSeminars in diagnostic pathology Vol. 33; no. 3; p. 141
Main Authors Kashyap, Seema, Meel, Rachna, Singh, Lata, Singh, Mithalesh
Format Journal Article
LanguageEnglish
Published United States 01.05.2016
Subjects
Humans
Melanoma - pathology
Melanoma - therapy
Prognosis
Uvea - pathology
Uveal Neoplasms - pathology
Uveal Neoplasms - therapy
Uveal diseases
Melanoma
Molecular Pathology
Ocular neoplasms
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Summary:Uveal melanoma is the most common primary intraocular malignancy in adults. It is associated with a high rate of distant tumor spread and consequent mortality. Unlike retinoblastoma, for which treatment advances over the last few decades have resulted in a dramatic improvement in survival, outcomes for patients with uveal melanoma remain unchanged. Despite improvement in local control of this tumor, roughly 50% of patients develop metastatic disease within 15 years. Delays in diagnosis and marked vascularity of this tumor may underlie that situation. Tumor size, location, histopathologic appearance, cytogenetic abnormalities, and molecular profiling are used in prognostication. The revised 7th edition of the American Joint Committee on Cancer (AJCC) manual has presented new information that may improve that process as well. Herein, we review current knowledge on uveal melanoma.
ISSN:0740-2570
1930-1111
DOI:10.1053/j.semdp.2015.10.005