Adverse Effects of Perfluorooctane Sulfonate on the Liver and Relevant Mechanisms

• Published in: Toxics (Basel) Vol. 10; no. 5; p. 265
• Main Authors: Wang, Pingwei, Liu, Dongge, Yan, Shuqi, Cui, Jiajing, Liang, Yujun, Ren, Shuping
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 19.05.2022; MDPI
• Subjects: Bans; Bioaccumulation; Drinking water; Enzymes; Fatty acids; Gene expression; hepatic function; Hepatocytes; Ingestion; Kitchen utensils; Lipids; Liver; liver injury; Metabolism; Occupational exposure; Occupational health; Perfluoroalkyl & polyfluoroalkyl substances; perfluorooctane sulfonate; Perfluorooctane sulfonic acid; PFAS; PFOS; Pollutants; Review; Side effects; Sulfonates; Toxicity; Utensils; United States > US; China; hepatic function; liver injury; liver; perfluorooctane sulfonate; PFAS; PFOS
• ISSN: 2305-6304; 2305-6304
• DOI: 10.3390/toxics10050265

Perfluorooctane sulfonate (PFOS) is a persistent, widely present organic pollutant. PFOS can enter the human body through drinking water, ingestion of food, contact with utensils containing PFOS, and occupational exposure to PFOS, and can have adverse effects on human health. Increasing research shows that the liver is the major target of PFOS, and that PFOS can damage liver tissue and disrupt its function; however, the exact mechanisms remain unclear. In this study, we reviewed the adverse effects of PFOS on liver tissue and cells, as well as on liver function, to provide a reference for subsequent studies related to the toxicity of PFOS and liver injury caused by PFOS.