Saliva – a new opportunity for fluid biopsy

• Published in: Clinical chemistry and laboratory medicine Vol. 61; no. 1; pp. 4 - 32
• Main Authors: Huang, Zhijie, Yang, Xiaoxia, Huang, Yisheng, Tang, Zhengming, Chen, Yuanxin, Liu, Hongyu, Huang, Mingshu, Qing, Ling, Li, Li, Wang, Qin, Jie, Zhuye, Jin, Xin, Jia, Bo
• Format: Journal Article
• Language: English
• Published: Germany De Gruyter 27.01.2023; Walter De Gruyter & Company
• Subjects: Biomarkers; Biomarkers - analysis; Biomolecules; Biopsy; Diagnosis; DNA methylation; Early Diagnosis; Exocrine glands; Genomics; Hospitals; Humans; Laboratories; Metabolites; Microbiota; Microorganisms; oral diseases; Saliva; Saliva - chemistry; salivaomics; salivary diagnosis; Surgery; Systemic diseases; oral diseases; salivaomics; systemic diseases; biomarkers; salivary diagnosis
• ISSN: 1434-6621; 1437-4331
• DOI: 10.1515/cclm-2022-0793

Saliva is a complex biological fluid with a variety of biomolecules, such as DNA, RNA, proteins, metabolites and microbiota, which can be used for the screening and diagnosis of many diseases. In addition, saliva has the characteristics of simple collection, non-invasive and convenient storage, which gives it the potential to replace blood as a new main body of fluid biopsy, and it is an excellent biological diagnostic fluid. This review integrates recent studies and summarizes the research contents of salivaomics and the research progress of saliva in early diagnosis of oral and systemic diseases. This review aims to explore the value and prospect of saliva diagnosis in clinical application.