Halogenation Strategies In Natural Product Biosynthesis

Halogenation is a frequent modification of secondary metabolites and can play a significant role in establishing the bioactivity of a compound. Enzymatic halogenation through oxidative mechanisms is the most common route to these metabolites, though direct halogenation via halide anion incorporation...

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Bibliographic Details
Published inChemistry & biology Vol. 15; no. 2; pp. 99 - 109
Main Authors Neumann, Christopher S., Fujimori, Danica Galonić, Walsh, Christopher T.
Format Journal Article
LanguageEnglish
Published United States Elsevier Ltd 01.02.2008
Subjects
Biological Products - biosynthesis
Biological Products - genetics
Biological Products - metabolism
Halogenation
Halogens - metabolism
Multigene Family
Peroxidases - metabolism
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Summary:Halogenation is a frequent modification of secondary metabolites and can play a significant role in establishing the bioactivity of a compound. Enzymatic halogenation through oxidative mechanisms is the most common route to these metabolites, though direct halogenation via halide anion incorporation is also known to proceed through both enzymatic and nonenzymatic pathways. In this article, we review the current state of knowledge regarding the mechanisms of these transformations, highlight applications of this knowledge, and propose future opportunities and challenges for the field.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1074-5521
1879-1301
DOI:10.1016/j.chembiol.2008.01.006