Mechanisms of deep brain stimulation

Deep brain stimulation (DBS) is widely used for the treatment of movement disorders including Parkinson's disease, essential tremor, and dystonia and, to a lesser extent, certain treatment-resistant neuropsychiatric disorders including obsessive-compulsive disorder. Rather than a single unifyin...

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Bibliographic Details
Published inJournal of neurophysiology Vol. 115; no. 1; pp. 19 - 38
Main Authors Herrington, Todd M., Cheng, Jennifer J., Eskandar, Emad N.
Format Journal Article
LanguageEnglish
Published United States American Physiological Society 01.01.2016
SeriesNeurobiology of Deep Brain Stimulation
Subjects
Animals
Brain Waves
Call for Papers
Deep Brain Stimulation
Dyskinesias - physiopathology
Dyskinesias - therapy
Humans
Parkinson Disease - physiopathology
Parkinson Disease - therapy
tremor
Parkinson's disease
basic science of clinical practice
dystonia
obsessive-compulsive disorder
deep brain stimulation
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Abstract Deep brain stimulation (DBS) is widely used for the treatment of movement disorders including Parkinson's disease, essential tremor, and dystonia and, to a lesser extent, certain treatment-resistant neuropsychiatric disorders including obsessive-compulsive disorder. Rather than a single unifying mechanism, DBS likely acts via several, nonexclusive mechanisms including local and network-wide electrical and neurochemical effects of stimulation, modulation of oscillatory activity, synaptic plasticity, and, potentially, neuroprotection and neurogenesis. These different mechanisms vary in importance depending on the condition being treated and the target being stimulated. Here we review each of these in turn and illustrate how an understanding of these mechanisms is inspiring next-generation approaches to DBS.
AbstractList Deep brain stimulation (DBS) is widely used for the treatment of movement disorders including Parkinson's disease, essential tremor, and dystonia and, to a lesser extent, certain treatment-resistant neuropsychiatric disorders including obsessive-compulsive disorder. Rather than a single unifying mechanism, DBS likely acts via several, nonexclusive mechanisms including local and network-wide electrical and neurochemical effects of stimulation, modulation of oscillatory activity, synaptic plasticity, and, potentially, neuroprotection and neurogenesis. These different mechanisms vary in importance depending on the condition being treated and the target being stimulated. Here we review each of these in turn and illustrate how an understanding of these mechanisms is inspiring next-generation approaches to DBS.
Deep brain stimulation (DBS) is widely used for the treatment of movement disorders including Parkinson's disease, essential tremor, and dystonia and, to a lesser extent, certain treatment-resistant neuropsychiatric disorders including obsessive-compulsive disorder. Rather than a single unifying mechanism, DBS likely acts via several, nonexclusive mechanisms including local and network-wide electrical and neurochemical effects of stimulation, modulation of oscillatory activity, synaptic plasticity, and, potentially, neuroprotection and neurogenesis. These different mechanisms vary in importance depending on the condition being treated and the target being stimulated. Here we review each of these in turn and illustrate how an understanding of these mechanisms is inspiring next-generation approaches to DBS.Deep brain stimulation (DBS) is widely used for the treatment of movement disorders including Parkinson's disease, essential tremor, and dystonia and, to a lesser extent, certain treatment-resistant neuropsychiatric disorders including obsessive-compulsive disorder. Rather than a single unifying mechanism, DBS likely acts via several, nonexclusive mechanisms including local and network-wide electrical and neurochemical effects of stimulation, modulation of oscillatory activity, synaptic plasticity, and, potentially, neuroprotection and neurogenesis. These different mechanisms vary in importance depending on the condition being treated and the target being stimulated. Here we review each of these in turn and illustrate how an understanding of these mechanisms is inspiring next-generation approaches to DBS.
Author Eskandar, Emad N.
Cheng, Jennifer J.
Herrington, Todd M.
Author_xml – sequence: 1
  givenname: Todd M.
  surname: Herrington
  fullname: Herrington, Todd M.
  organization: Nayef Al-Rodhan Laboratories, Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts;, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; and
– sequence: 2
  givenname: Jennifer J.
  surname: Cheng
  fullname: Cheng, Jennifer J.
  organization: Nayef Al-Rodhan Laboratories, Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts;, Department of Neurosurgery, The Johns Hopkins Hospital, Baltimore, Maryland
– sequence: 3
  givenname: Emad N.
  surname: Eskandar
  fullname: Eskandar, Emad N.
  organization: Nayef Al-Rodhan Laboratories, Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26510756$$D View this record in MEDLINE/PubMed
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Keywords tremor
Parkinson's disease
basic science of clinical practice
dystonia
obsessive-compulsive disorder
deep brain stimulation
Language English
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Snippet Deep brain stimulation (DBS) is widely used for the treatment of movement disorders including Parkinson's disease, essential tremor, and dystonia and, to a...
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StartPage 19
SubjectTerms Animals
Brain Waves
Call for Papers
Deep Brain Stimulation
Dyskinesias - physiopathology
Dyskinesias - therapy
Humans
Parkinson Disease - physiopathology
Parkinson Disease - therapy
Title Mechanisms of deep brain stimulation
URI https://www.ncbi.nlm.nih.gov/pubmed/26510756
https://www.proquest.com/docview/1760912568
https://pubmed.ncbi.nlm.nih.gov/PMC4760496
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