A laparoscopic risk-adjusted model to predict major complications after primary debulking surgery in ovarian cancer: A single-institution assessment

• Published in: Gynecologic oncology Vol. 142; no. 1; pp. 19 - 24
• Main Authors: Vizzielli, G, Costantini, B, Tortorella, L, Pitruzzella, I, Gallotta, V, Fanfani, F, Gueli Alletti, S, Cosentino, F, Nero, C, Scambia, G, Fagotti, A
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2016
• Subjects: Adult; Aged; Aged, 80 and over; Female; Gynecologic Surgical Procedures - adverse effects; Gynecologic Surgical Procedures - methods; Gynecologic Surgical Procedures - statistics & numerical data; Hematology, Oncology and Palliative Medicine; Humans; Italy - epidemiology; Laparoscopy; Laparoscopy - adverse effects; Laparoscopy - methods; Laparoscopy - statistics & numerical data; Middle Aged; Models, Statistical; Obstetrics and Gynecology; Ovarian cancer; Ovarian Neoplasms - epidemiology; Ovarian Neoplasms - pathology; Ovarian Neoplasms - surgery; Post-operative complications; Postoperative Complications - epidemiology; Postoperative Complications - etiology; Predictive model; Reproducibility of Results; Risk Assessment - methods; Young Adult; Laparoscopy; Post-operative complications; Predictive model; Ovarian cancer
• ISSN: 0090-8258; 1095-6859
• DOI: 10.1016/j.ygyno.2016.04.020

Abstract Objective To develop and validate a simple adjusted laparoscopic score to predict major postoperative complications after primary debulking surgery (PDS) in advanced epithelial ovarian cancer (AEOC). Methods From January 2006 to June 2015, preoperative, intraoperative, and post-operative outcome data from patients undergoing staging laparoscopy (S-LPS) before receiving PDS (n = 555) were prospectively collected in an electronic database and retrospectively analyzed. Major complications were defined as levels 3 to 5 of MSKCC classification. On the basis of a multivariate regression model, the score was developed using a random two-thirds of the population (n = 370) and was validated on the remaining one-third patients (n = 185). Results Major complication rate was 18.3% (102/555). Significant predictors included in the scoring system were: poor performance status, presence of ascites (> 500 cm3 ), CA125 serum level (> 1000 U/ml), and high laparoscopic tumor load (predictive index value, PIV ≥ 8). The mean risk of developing major postoperative complications was 3.7% in patients with score 0 to 2, 13.2% in patients with score 3 to 5, 37.1% in patients with score 6 to 8. In the validation population, the predicted risk of major complications was 17.8% (33/185) versus a 16.7% (31/185) observed risk (C-statistic index = 0.790). Conclusion This new score may accurately predict a patient's postoperative outcome. Early identification of high-risk patients could help the surgeon to adopt tailored strategies on individual basis.